EFEK ANTIHIPERTENSI EKSTRAK ETANOL UMBI WORTEL (Daucus carota L.) PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT (MSG)

Ulfa, Madu Pratiwi (2018) EFEK ANTIHIPERTENSI EKSTRAK ETANOL UMBI WORTEL (Daucus carota L.) PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT (MSG). Skripsi thesis, Universitas Wahid Hasyim Semarang.

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Abstract

The previous studies reported that carrot juice had an antihypertensive effect. This study aims to prove the antihypertensives effects of carrot tuber ethanol extract (CTEE) in MSG-induced hypertensive rats and to set the pattern of its antihypertensive effect based on dose. This study used randomized pre-test and post-test matched control group design. CTEE was prepared by using maceration method with ethanol solvent 70%. The hypertension rats induced with MSG 100 mg/kg BW/day for 14 days. The 25 hypertension rats were grouped into five treatment groups, hypertension control (CMC-Na 0,5% 12,5 mL/kg BW/day), positive control (furosemide 5,04 mg/kg BW), and CTEE (100 ; 200 and 400) mg/kg BW. The extracts were given once a day for 14 days orally. The systolic and diastolic blood pressure of hypertensive rats before and after treatment statistically analyzed by Wilcoxon test or T paired, while the blood pressure decrease of hypertensive rats that got treated with CTEE was analyzed by one way ANOVA test. The results showed that CTEE (100, 200 and 400) mg/kg BW/day for 14 days had antihypertensive effect on MSG-induced hypertensive rats. However, the antihypertensive effect of CTEE does not follow a dose-dependent pattern in both systolic and diastolic blood pressure.

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