PENGARUH LAMA PENYIMPANAN TERHADAP STABILITAS FISIKA KIMIA PADA SPIRONOLAKTON DAN FUROSEMID DALAM SEDIAAN RACIKAN KAPSUL

Tiara, Eka Wulandar (2018) PENGARUH LAMA PENYIMPANAN TERHADAP STABILITAS FISIKA KIMIA PADA SPIRONOLAKTON DAN FUROSEMID DALAM SEDIAAN RACIKAN KAPSUL. Skripsi thesis, Universitas Wahid Hasyim Semarang.

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Abstract

Doctors' prescriptions which contain mixtures or concoction medicine are prepared in a dosage form such as a capsule. The shape sifting of medicine may be able to reduce both physical and chemical stability. Furthermore, the length of storage also affects toward the dosage form, either the physical or chemical. The aim of this study was to determine the effect of long storage medicine toward the physical and chemical stability of capsules concoction containing spironolactone and furosemide. The capsule concoction from RSUD Kelet Jepara Installation was stored at normal room temperature for 14 days storage time. The investigation was conducted periodically at 1st, 5th, 9th and 14th day. Physical stability was observed organoleptically. Moreover, the spironolactone and furosemide was observed by using KCKT. The spironolactone and furosemide data obtained were analyzed statistically using linear regression. In order to observe the chemical stability, this study also used one way ANOVA at 95% confidence level. The results showed that the physical stability of the capsule concoction was still stable at the 1st, 5th, 9th and 14th days. The preparation of the 1st day capsule showed white color, fine powder, odorless and bitter taste. By the same token, in the 14th day storage, the chemical stability remained stable even though there was a decrease in levels but the content of spironolactone and furosemide within 14 days did not differ significantly.

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