EFEK ANTIHIPERTENSI EKSTRAK ETANOL DAUN CINCAU HIJAU (Premna oblongifelia Merr.) PADA TIKUS HIPERTENSI YANG DI INDUKSI MONOSODIUM GLUTAMAT (MSG)

Tisa, Imas Nurmayanti (2018) EFEK ANTIHIPERTENSI EKSTRAK ETANOL DAUN CINCAU HIJAU (Premna oblongifelia Merr.) PADA TIKUS HIPERTENSI YANG DI INDUKSI MONOSODIUM GLUTAMAT (MSG). Skripsi thesis, Universitas Wahid Hasyim Semarang.

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Abstract

Green grass cincau jelly leaves had an antihypertension effect. This research aimed to prove the antihypertension effect of green cincau leaves ethanol extract (GCLEE) to MSG-induced hypertension rats and to determine its antihypertension effect based on dose. This research using randomized pre-test and post-test matched control group design. GCLEE produces by maceration method. The sample were 25 male Wistar rats treated with MSG 100 mg/kg BW/day (p.o) for 14 days. Hypertension rats were divided into five treatment groups, are hypertension control group (CMC-Na 12.5 mg/kg BW/day), positive control group (furosemid 5.04 mg/kg BW/day), and GCLEE ( 67.5, 135 and 270) mg/kg BW/day. The extracts were given once a day for 14 days. The data were differences in systolic and diastolic blood pressure before and after extracts treatment analyzed by the paired T-test or Wilcoxon. The decrease in blood pressure after treatment were statistically analyzed by One Way ANOVA. The result shows that GCLEE (67.5, 135 dan 270 mg/kg BW/day) had the antihypertension effect on MSG-induced hypertension rats. However, the antihypertension effect of the GCLEE does not follow a dose-dependent pattern.

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