PENGARUH PENAMBAHAN TEPUNG UMBI PORANG (Amorphophallus oncophyllus) SEBAGAI BAHAN PENGHANCUR SECARA INTERNAL-EKSTERNAL TERHADAP SIFAT FISIK DAN DISOLUSI TABLET PARASETAMOL

Sulistiyowati, Sulistiyowati (2018) PENGARUH PENAMBAHAN TEPUNG UMBI PORANG (Amorphophallus oncophyllus) SEBAGAI BAHAN PENGHANCUR SECARA INTERNAL-EKSTERNAL TERHADAP SIFAT FISIK DAN DISOLUSI TABLET PARASETAMOL. Skripsi thesis, Universitas Wahid Hasyim Semarang.

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Abstract

Porang tuber’s flour contain glucomannan polymer that has characteristics as cellulose as well as galaktomanan. Glucomannan able to swell in water up to 200% of original size, there for can be used as a tablet disintegrant. The purpose of this study was to determine the effect of tuber flour as a disintegrant added as internally-externally phased of physicochemical properties and dissolution of paracetamol tablet. Paracetamol tablets were made in five formulas in comparison FI 100:0%; FII 75:25%; FIII 50:50%; FIV 25:75% and FV 0:100%, based on variation in disintegrating agent added. Paracetamol tablets made by wet granulation method. Granul obtained tested for characteristic properties including flow time, reposangle and tapping index. Granul mixture compressed using single punch machine tablet. Tablets obtained tested for physicochemical properties characteristics including: weight uniformity, hardness, friability, disintegration time and dissolution of the drug. The data analyzed descriptivelly and statistically using parametric and non-parametric test. The results showed that the physical characteristics of the granules of all formulas were within the acceptance criteria, and for the dissolution of parasetamol tablets three formulas were within the acceptance criteria and two formulas out of the acceptance criteria. Physicochemical characteristics of tablets from FIII including friability was 0.59% lower than the others, disintegration time was 02.79 minutes faster than the others formulas, but the released of the active substance was 75,4% out of the acceptance criteria.

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