FORMULASI GEL EKSTRAK METANOL DAUN KERSEN (Muntingia calabura L.) SEBAGAI PENYEMBUH LUKA SAYAT DENGAN VARIASI KONSENTRASI CMC-NA

Hafif, Widhodho (2018) FORMULASI GEL EKSTRAK METANOL DAUN KERSEN (Muntingia calabura L.) SEBAGAI PENYEMBUH LUKA SAYAT DENGAN VARIASI KONSENTRASI CMC-NA. Skripsi thesis, Universitas Wahid Hasyim Semarang.

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Abstract

Kersen leaf (Muntingia calabura L.) contains flavonoid and saponin that accelerate healing of cuts. Gel preparation is good for cuts due to more convenient use. The preparation is made using Na-CMC base as a gelling agent. Excess usage of CMCNA is easily soluble in water at any temperature. The purpose of this research is to determine the effect of Na-CMC concentration variation of methanol extract of kersen leaves against physical properties, chemical properties and wound healing ability of the gel preparation. Methanol extract of kersen leaves (MEKL) was obtained by maceration. The formula methanol extract of kersen leaf was made with variation of Na-CMC FI base 4%, FII 5%, FIII 6%. Gel tested physical and chemical properties include organoleptic, pH, viscosity, homogeneity, adhesion, dispersion. Data of physical properties (pH, viscosity, adhesiveness, dispersion) obtained gel were analyzed using linear regression correlation, organoleptic test result, homogeneity and wound healing were analyzed descriptively. The results showed that the methanol extract of kersen leaves has a soft texture, typical smell of cherry leaves, homogeneous, and pH qualified skin pH 5,6-6,2. Increased consentation of Na-CMC in the methanol extract of kersen leaves increases viscosity and adhesion, but decreases the gel density. Variation of Na-CMC concentration (4%, 5%, 6%) MEKL can cure wounds comparable.

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